Modern Molecular Biology:: Approaches for Unbiased Discovery in Cancer Research (Applied Bioinformatics and Biostatistics in Cancer Research)

Modern Molecular Biology:: Approaches for Unbiased Discovery in Cancer Research (Applied Bioinformatics and Biostatistics in Cancer Research) Review

Modern Molecular Biology:: Approaches for Unbiased Discovery in Cancer Research (Applied Bioinformatics and Biostatistics in Cancer Research) Overview

Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to these macromolecules that occur in diseases such as cancer. In this volume, we will explore the modern approaches used to characterize these macromolecules in an unbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly interpreted by biostatistical/bioinformatics analyses, can be exploited for the prevention, diagnosis, and treatment of human cancers. The purpose of this volume is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research. Advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression will be overviewed. These include the strategies employed in modern genomics, gene expression analysis, and proteomics.

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Dr. Shameema Sarker, Chair, University of Phoenix, Discovery Channel - "Curiosity"

Shameema Sarker, PhD Molecular Biologist and University of Phoenix College of Natural Sciences Lead Faculty Shameema has a doctoral degree in Molecular Biology & Biochemistry from Wesleyan University, CT, and has done her post-doctoral research at the University of Colorado Health Sciences Center in Denver, CO. She has taught Biology and Chemistry at the University of Arizona and several Community colleges, and has been involved in research for the past 18 years. She has been teaching at the University of Phoenix since 2006, and is a Lead Faculty for the College of Natural Sciences and also a Faculty Council Member at the University of Phoenix. Currently, she is a Senior Research Scientist with the Biodesign Institute at the Arizona State University, and a member of the American Society for Microbiology. Shameema has been involved in wide-ranging projects, from national defense-related ones that employ hand-held bio-terrorism detection kits, to infectious diseases involving pathogens like Norovirus, Hepatitis B virus, Salmonella, to cancer and HIV-related researches. Her more recent research involves developing 3-D organotypic cell culture models (eg, large and small intestine, lung, bladder, neuronal) including complex 3-D immunocompetent co-culture models for studying host pathogen interactions, as well as investigating the molecular mechanisms of infectious diseases. A major aspect of her research involves understanding the effects of spaceflight on microbial ...

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